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For instance, certain NOX members, such as NOX4, are overexpressed in various types of cancer (e.g., hepatocellular carcinoma and renal cell carcinoma) [19, 20]

Chromatin immunoprecipitation (ChIP) demonstrated increased occupancy of H2AX and decreased occupancy of all three acetylation marks at DSBs in both IDH1 inhibitor-treated and TMLHE-knockdown cells (Fig

However, in the Phase I/II ACTION-Galactosemia study, which focused on adults, treatment with govorestat resulted in a drop in galactitol concentrations, according to Applied Therapeutics

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